Population-based resequencing of APOA1 in 10,330 individuals: spectrum of genetic variation, phenotype, and comparison with extreme phenotype approach.

Rare genetic variants, identified by in-detail resequencing of loci, may contribute to complex traits. We used the apolipoprotein A-I gene (APOA1), a major high-density lipoprotein (HDL) gene, and population-based resequencing to determine the spectrum of genetic variants, the phenotypic characteris...

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Autores principales: Christiane L Haase, Ruth Frikke-Schmidt, Børge G Nordestgaard, Anne Tybjærg-Hansen
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2012-01-01
Colección:PLoS Genetics
Acceso en línea:http://europepmc.org/articles/PMC3510059?pdf=render
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