AKT inhibition in the central nervous system induces signaling defects resulting in psychiatric symptomatology

Abstract Background Changes in the expression and activity of the AKT oncogene play an important role in psychiatric disease. We present translational data assessing the role of AKT in psychiatric symptoms. Methods (1) We assessed the protein activity of an AKT3 mutant harboring a PH domain mutation...

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Main Authors: Apostolia-Maria Tsimberidou, Antonis Skliris, Alan Valentine, Jamie Shaw, Ursula Hering, Henry Hiep Vo, Tung On Chan, Roger S. Armen, Jeffrey R. Cottrell, Jen Q. Pan, Philip N. Tsichlis
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2022-05-01
Serier:Cell & Bioscience
Fag:
AKT
PI3K
Advanced cancer
Clinical trial
Central nervous system
Mental illness
Online adgang:https://doi.org/10.1186/s13578-022-00793-8
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