Role of the HIV-1 Reservoir to Maintain Viral Suppression in a Simplified Strategy for the Long-Term Management of HIV-1 Infection (The SIMPL’HIV Trial)

HIV-1 reservoir size and dynamics are promising parameters to ensure the safe prescription of simplified maintenance antiretroviral therapy in chronically HIV-1 infected patients. In the SIMPL’HIV trial, HIV-1 DNA was quantified in peripheral blood mononuclear cells obtained at baseline and week 48...

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Main Authors: Mattia Branca, Annalisa Marinosci, Delphine Sculier, Gilles Wandeler, Sabine Yerly, Marcel Stoeckle, Enos Bernasconi, Dominique L. Braun, Kathrin Neumann, Pietro Vernazza, Matthias Cavassini, Marta Buzzi, Laurent A. Decosterd, Patrick Schmid, Andreas Limacher, Huldrych F. Günthard, Karin J. Metzner, Alexandra Calmy
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-05-01
Colecção:Frontiers in Virology
Assuntos:
HIV-1 reservoir
dolutegravir+emtricitabine
dual therapy
cART
HIV-1 RNA
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fviro.2022.855437/full
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