Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient <i>in vitro</i> Clearance of iPSCs and iPSC-Macrophages

Induced pluripotent stem cells (iPSCs) offer great promise for the field of regenerative medicine, and iPSC-derived cells have already been applied in clinical practice. However, potential contamination of effector cells with residual pluripotent cells (e.g., teratoma-initiating cells) or effector c...

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Autori principali: Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-04-01
Serie:International Journal of Molecular Sciences
Soggetti:
inducible caspase 9
suicide genes
iPSC
macrophages
cell therapy
Accesso online:https://www.mdpi.com/1422-0067/21/7/2481
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