Use of Cell and Genome Modification Technologies to Generate Improved “Off-the-Shelf” CAR T and CAR NK Cells

Por Michael A. Morgan, Michael A. Morgan, Hildegard Büning, Hildegard Büning, Martin Sauer, Axel Schambach, Axel Schambach, Axel Schambach
Publicado em 2020-08-01

Synthetic Notch-Receptor-Mediated Transmission of a Transient Signal into Permanent Information via CRISPR/Cas9-Based Genome Editing

Por Malte Sgodda, Susanne Alfken, Axel Schambach, Reto Eggenschwiler, Pawel Fidzinski, Michael Hummel, Tobias Cantz
Publicado em 2020-08-01

Genome-Wide Analysis of Alpharetroviral Integration in Human Hematopoietic Stem/Progenitor Cells

Por Arianna Moiani, Julia Debora Suerth, Francesco Gandolfi, Ermanno Rizzi, Marco Severgnini, Gianluca De Bellis, Axel Schambach, Fulvio Mavilio
Publicado em 2014-05-01

Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient <i>in vitro</i> Clearance of iPSCs and iPSC-Macrophages

Por Alexandra Lipus, Ewa Janosz, Mania Ackermann, Miriam Hetzel, Julia Dahlke, Theresa Buchegger, Stephanie Wunderlich, Ulrich Martin, Toni Cathomen, Axel Schambach, Thomas Moritz, Nico Lachmann
Publicado em 2020-04-01

Biosafety Studies of a Clinically Applicable Lentiviral Vector for the Gene Therapy of Artemis-SCID

Por Sabine Charrier, Chantal Lagresle-Peyrou, Valentina Poletti, Michael Rothe, Grégory Cédrone, Bernard Gjata, Fulvio Mavilio, Alain Fischer, Axel Schambach, Jean-Pierre de Villartay, Marina Cavazzana, Salima Hacein-Bey-Abina, Anne Galy
Publicado em 2019-12-01

Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model.

Por Shamim H Rahman, Johannes Kuehle, Christian Reimann, Tafadzwa Mlambo, Jamal Alzubi, Morgan L Maeder, Heimo Riedel, Paul Fisch, Tobias Cantz, Cornelia Rudolph, Claudio Mussolino, J Keith Joung, Axel Schambach, Toni Cathomen
Publicado em 2015-05-01

Ex Vivo/In vivo Gene Editing in Hepatocytes Using “All-in-One” CRISPR-Adeno-Associated Virus Vectors with a Self-Linearizing Repair Template

Por Simon Alexander Krooss, Zhen Dai, Florian Schmidt, Alice Rovai, Julia Fakhiri, Akshay Dhingra, Qinggong Yuan, Taihua Yang, Asha Balakrishnan, Lars Steinbrück, Sangar Srivaratharajan, Michael Peter Manns, Axel Schambach, Dirk Grimm, Jens Bohne, Amar Deep Sharma, Hildegard Büning, Michael Ott
Publicado em 2020-01-01

Successful Preclinical Development of Gene Therapy for Recombinase-Activating Gene-1-Deficient SCID

Por Laura Garcia-Perez, Marja van Eggermond, Lieke van Roon, Sandra A. Vloemans, Martijn Cordes, Axel Schambach, Michael Rothe, Dagmar Berghuis, Chantal Lagresle-Peyrou, Marina Cavazzana, Fang Zhang, Adrian J. Thrasher, Daniela Salvatori, Pauline Meij, Anna Villa, Jacques J.M. Van Dongen, Jaap-Jan Zwaginga, Mirjam van der Burg, H. Bobby Gaspar, Arjan Lankester, Frank J.T. Staal, Karin Pike-Overzet
Publicado em 2020-06-01