Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells

Atractylenolide-1 (AT-1), a natural active ingredient extracted from Atractylodes macrocephala, was reported to have good anti-fibrotic and anti-inflammatory effects. Osteogenic changes induced by the inflammation of valve interstitial cells (VICs) play a role in the development of calcified aortic...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Jie Wang, Penghua Zhang, Jing Zhang, Zhaohui Ma, Xingqin Tian, Yan Liu, Guanghui Lv, Linghang Qu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2022-04-01
Colecção:Frontiers in Pharmacology
Assuntos:
Atractylenolide-1
calcification
PI3K
FLT3
HIF1-α
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fphar.2022.899775/full
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados