Alcohol-induced suppression of KDM6B dysregulates the mineralization potential in dental pulp stem cells

Epigenetic changes, such as alteration of DNA methylation patterns, have been proposed as a molecular mechanism underlying the effect of alcohol on the maintenance of adult stem cells. We have performed genome-wide gene expression microarray and DNA methylome analysis to identify molecular alteratio...

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Main Authors: Michael Hoang, Jeffrey J. Kim, Yiyoung Kim, Elizabeth Tong, Benjamin Trammell, Yao Liu, Songtao Shi, Chang-Ryul Lee, Christine Hong, Cun-Yu Wang, Yong Kim
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2016-07-01
Series:Stem Cell Research
Assuntos:
Alcohol
Dental pulp stem cells (DPSCs)
Epigenetics
DNA methylation
Osteogenic differentiation
Odontogenic differentiation
Mineralization
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S1873506116300599
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