Microsomal Prostaglandin E Synthase-1 Deficiency Exacerbates Pulmonary Fibrosis Induced by Bleomycin in Mice

Microsomal prostaglandin E2 synthase-1 (mPGES-1), an inducible enzyme that converts prostaglandin H2 (PGH2) to prostaglandin E2 (PGE2), plays an important role in a variety of diseases. So far, the role of mPGES-1 in idiopathic pulmonary fibrosis (IPF) remained unknown. The current study aimed to in...

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Hlavní autoři: Bo Wei, Linhong Cai, Dan Sun, Yanhua Wang, Cairui Wang, Xiaoyu Chai, Feng Xie, Ming Su, Fangrui Ding, Jie Liu, Jichun Yang, Youfei Guan, Xinmin Liu
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2014-04-01
Edice:Molecules
Témata:
microsomal prostaglandin E synthase-1
idiopathic pulmonary fibrosis
prostaglandin E2
E prostanoid receptor 2
focal adhesion kinase
On-line přístup:http://www.mdpi.com/1420-3049/19/4/4967
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