In Situ Gel Incorporating Disulfiram Nanoparticles Rescues the Retinal Dysfunction via ATP Collapse in Otsuka Long–Evans Tokushima Fatty Rats

We attempted to design an ophthalmic in situ gel formulation incorporating disulfiram (DIS) nanoparticles (Dis-NPs/ISG) and demonstrated the therapeutic effect of Dis-NPs/ISG on retinal dysfunction in 15-month-old Otsuka Long–Evans Tokushima Fatty (OLETF) rats, a rat model of diabetes. The DIS parti...

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Hlavní autoři: Saori Deguchi, Fumihiko Ogata, Mizuki Yamaguchi, Misa Minami, Hiroko Otake, Kazutaka Kanai, Naohito Kawasaki, Noriaki Nagai
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-09-01
Edice:Cells
Témata:
nanoparticles
disulfiram
diabetic retinopathy
electroretinogram
diethyldithiocarbamate
On-line přístup:https://www.mdpi.com/2073-4409/9/10/2171
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