Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treated With Tyrosine Kinase Inhibitors

Natural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation enc...

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Main Authors: Paulo Rodrigues-Santos, Nelson López-Sejas, Jani Sofia Almeida, Lenka Ruzičková, Patricia Couceiro, Vera Alves, Carmen Campos, Corona Alonso, Raquel Tarazona, Paulo Freitas-Tavares, Rafael Solana, Manuel Santos-Rosa
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-11-01
Colecção:Frontiers in Immunology
Assuntos:
aging
CML
NK receptors
activation markers
differentiation markers
cytokines
Acesso em linha:https://www.frontiersin.org/article/10.3389/fimmu.2018.02587/full
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