Biotherapy of Brain Tumors with Phosphatidylserine-Targeted Radioiodinated SapC-DOPS Nanovesicles

Glioblastoma multiforme (GBM), a common type of brain cancer, has a very poor prognosis. In general, viable GBM cells exhibit elevated phosphatidylserine (PS) on their membrane surface compared to healthy cells. We have developed a drug, saposin C-dioleoylphosphatidylserine (SapC-DOPS), that selecti...

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Hlavní autoři: Harold W. Davis, Subrahmanya D. Vallabhapurapu, Zhengtao Chu, Michael A. Wyder, Kenneth D. Greis, Venette Fannin, Ying Sun, Pankaj B. Desai, Koon Y. Pak, Brian D. Gray, Xiaoyang Qi
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI AG 2020-08-01
Edice:Cells
Témata:
SapC-DOPS nanovesicles
radiation therapy
brain tumor
glioblastoma multiforme
iodination
phosphatidylserine
On-line přístup:https://www.mdpi.com/2073-4409/9/9/1960
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