A randomised, double-blind, parallel-group trial to assess mercaptopurine versus placebo to prevent or delay recurrence of Crohn’s disease following surgical resection (TOPPIC)

Background: Crohn’s disease (CD) is a chronic, relapsing, inflammatory bowel disease. Up to 65% of patients with CD require an operation to control the disease within 10 years. Both endoscopic and clinical recurrence is common within 2 years of operation, with re-operation rates cumulating at 5% of...

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Hauptverfasser: Jack Satsangi, Nicholas A Kennedy, Craig Mowat, Ian Arnott, Catriona Keerie, Steff Lewis, Holly Ennis
Format: Artigo
Sprache:Inglês
Veröffentlicht: NIHR Journals Library 2017-09-01
Schriftenreihe:Efficacy and Mechanism Evaluation
Schlagworte:
crohn’s disease
mercaptopurine
postoperative recurrence
Online Zugang:https://doi.org/10.3310/eme04040
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