Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae

Metformin may potentially reverse various age-related conditions; however, it is unclear whether metformin can also mitigate or delay the deterioration of immunological resilience that occurs in the context of infections that are commonly observed in older persons. We examined whether metformin prom...

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Bibliografiska uppgifter
Huvudupphovsmän: Grace C. Lee, Alvaro G. Moreira, Cecilia Hinojosa, Raymond Benavides, Caitlyn Winter, Audrey C. Anderson, Chang-Jui Chen, Noemi Borsa, Gabrielyd Hastings, Cody A. Black, Sarah M. Bandy, Alexander Shaffer, Marcos I. Restrepo, Sunil K. Ahuja
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2022-04-01
Serie:Frontiers in Aging
Ämnen:
Streptococcus pneumoniae
vaccine response
metformin
aging
pneumonia
Länkar:https://www.frontiersin.org/articles/10.3389/fragi.2022.736835/full
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