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Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases

Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism, negatively regulating pyruvate dehyrogenase complex (PDC) activity through phosphorylation. Inhibiting PDKs could upregulate PDC activity and drive cells into more aerobic metabolism. Therefore, PDKs are potential targets f...

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Detalhes bibliográficos
Main Authors: Xiaoli Zhou, Shanshan Yu, Jing Su, Liankun Sun
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2016-03-01
Colecção:International Journal of Molecular Sciences
Assuntos:
Acesso em linha:http://www.mdpi.com/1422-0067/17/3/340
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