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Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases
Pyruvate dehydrogenase kinases (PDKs) are key enzymes in glucose metabolism, negatively regulating pyruvate dehyrogenase complex (PDC) activity through phosphorylation. Inhibiting PDKs could upregulate PDC activity and drive cells into more aerobic metabolism. Therefore, PDKs are potential targets f...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
MDPI AG
2016-03-01
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Colecção: | International Journal of Molecular Sciences |
Assuntos: | |
Acesso em linha: | http://www.mdpi.com/1422-0067/17/3/340 |
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