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CLN3 deficient cells display defects in the ARF1-Cdc42 pathway and actin-dependent events.
Juvenile Batten disease (juvenile neuronal ceroid lipofuscinosis, JNCL) is a devastating neurodegenerative disease caused by mutations in CLN3, a protein of undefined function. Cell lines derived from patients or mice with CLN3 deficiency have impairments in actin-regulated processes such as endocyt...
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Main Authors: | , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
Public Library of Science (PLoS)
2014-01-01
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Serier: | PLoS ONE |
Online adgang: | http://europepmc.org/articles/PMC4008583?pdf=render |
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