CGRP and the Calcitonin Receptor are Co-Expressed in Mouse, Rat and Human Trigeminal Ganglia Neurons

The neuropeptide calcitonin gene-related peptide (CGRP) is expressed in the trigeminal ganglia, a key site in craniofacial pain and migraine. CGRP potently activates two receptors: the CGRP receptor and the AMY1 receptor. These receptors are heterodimers consisting of receptor activity-modifying pro...

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Main Authors: Tayla A. Rees, Andrew F. Russo, Simon J. O’Carroll, Debbie L. Hay, Christopher S. Walker
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2022-05-01
Sraith:Frontiers in Physiology
Ábhair:
CGRP—calcitonin gene-related peptide
migraine
headache
G protein-coupled receptor
trigeminal ganglia
amylin
Rochtain Ar Líne:https://www.frontiersin.org/articles/10.3389/fphys.2022.860037/full
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