An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.

The phosphoinositide-3-kinase (PI3K) pathway is commonly deregulated in breast cancer through several mechanisms, including PIK3CA mutation and loss of phosphatase and tensin homolog (PTEN) and inositol polyphosphate 4-phosphatase-II (INPP4B). We aimed to evaluate the predictive relevance of these b...

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Hlavní autoři: Aiko Sueta, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mitsuhiro Hayashi, Takashi Takeshita, Satoko Yamamoto, Hirotaka Iwase
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC4277449?pdf=render
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