Clinical and Molecular Assessment of Patients with Lynch Syndrome and Sarcomas Underpinning the Association with <i>MSH2</i> Germline Pathogenic Variants

Lynch syndrome (LS) is a hereditary cancer-predisposing syndrome associated most frequently with epithelial tumors, particularly colorectal (CRC) and endometrial carcinomas (EC). The aim of this study was to investigate the relationship between sarcomas and LS by performing clinical and molecular ch...

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Detalhes bibliográficos
Main Authors: Nathália de Angelis de Carvalho, Bianca Naomi Niitsuma, Vanessa Nascimento Kozak, Felipe D’almeida Costa, Mariana Petaccia de Macedo, Bruna Elisa Catin Kupper, Maria Letícia Gobo Silva, Maria Nirvana Formiga, Sahlua Miguel Volc, Samuel Aguiar Junior, Edenir Inez Palmero, José Cláudio Casali-da-Rocha, Dirce Maria Carraro, Giovana Tardin Torrezan
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2020-07-01
Colecção:Cancers
Assuntos:
Lynch syndrome
sarcoma
<i>MSH2</i> germline variant
hereditary cancer
mismatch repair deficiency
Acesso em linha:https://www.mdpi.com/2072-6694/12/7/1848
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