Recursive model for dose-time responses in pharmacological studies

Abstract Background Clinical studies often track dose-response curves of subjects over time. One can easily model the dose-response curve at each time point with Hill equation, but such a model fails to capture the temporal evolution of the curves. On the other hand, one can use Gompertz equation to...

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Main Authors: Saugato Rahman Dhruba, Aminur Rahman, Raziur Rahman, Souparno Ghosh, Ranadip Pal
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2019-06-01
Serier:BMC Bioinformatics
Fag:
Drug sensitivity prediction
Pharmacogenomic studies
HMS-LINCS
Joint dose-time modeling
Recursive modeling
Dose-response curve
Online adgang:http://link.springer.com/article/10.1186/s12859-019-2831-4
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