Biochemical characterization of actin assembly mechanisms with ALS-associated profilin variants

Eight separate mutations in the actin-binding protein profilin-1 have been identified as a rare cause of amyotrophic lateral sclerosis (ALS). Profilin is essential for many neuronal cell processes through its regulation of lipids, nuclear signals, and cytoskeletal dynamics, including actin filament...

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Main Authors: Xinbei Liu, Morgan L. Pimm, Brian Haarer, Andrew T. Brawner, Jessica L. Henty-Ridilla
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2022-04-01
Serier:European Journal of Cell Biology
Fag:
Profilin
Amyotrophic lateral sclerosis (ALS)
Actin
Formin
Cytoskeleton
Online adgang:http://www.sciencedirect.com/science/article/pii/S0171933522000152
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