Normoxic Tumour Extracellular Vesicles Modulate the Response of Hypoxic Cancer and Stromal Cells to Doxorubicin In Vitro

Extracellular vesicles (EV) secreted in the tumour microenvironment (TME) are emerging as major antagonists of anticancer therapies by orchestrating the therapeutic outcome through altering the behaviour of recipient cells. Recent evidence suggested that chemotherapeutic drugs could be responsible f...

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Autori principali: Laura Patras, Marcel H. A. M. Fens, Pieter Vader, Arjan Barendrecht, Alina Sesarman, Manuela Banciu, Raymond Schiffelers
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2020-08-01
Serie:International Journal of Molecular Sciences
Soggetti:
extracellular vesicles
doxorubicin
colon cancer
normoxia
hypoxia
macrophages
Accesso online:https://www.mdpi.com/1422-0067/21/17/5951
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