Cytotoxic Desulfated Saponin from Holothuria atra Predicted to Have High Binding Affinity to the Oncogenic Kinase PAK1: A Combined In Vitro and In Silico Study

Sea cucumbers have long been utilized in foods and Asiatic folk medicines for their nutritive and health benefits. Herein, three sea cucumber species were investigated and Holothuria atra showed the highest cytotoxicity among these. Next, a desulfated saponin, desulfated echinoside B (DEB), was puri...

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Main Authors: Md Shahinozzaman, Takahiro Ishii, Ryo Takano, Mohammad A. Halim, Md Amzad Hossain, Shinkichi Tawata
Format: Artigo
Jezik:Inglês
Izdano: Österreichische Apotheker-Verlagsgesellschaft m. b. H. 2018-08-01
Serija:Scientia Pharmaceutica
Teme:
Holothuria atra
desulfated echinoside B
molecular docking
molecular dynamics
p21-activated kinase 1
Online dostop:http://www.mdpi.com/2218-0532/86/3/32
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