The ratio of nicotinic acid to nicotinamide as a microbial biomarker for assessing cell therapy product sterility

Controlling microbial risks in cell therapy products (CTPs) is important for product safety. Here, we identified the nicotinic acid (NA) to nicotinamide (NAM) ratio as a biomarker that detects a broad spectrum of microbial contaminants in cell cultures. We separately added six different bacterial sp...

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Main Authors: Jiayi Huang, Liang Cui, Meenubharathi Natarajan, Paul W. Barone, Jacqueline M. Wolfrum, Yie Hou Lee, Scott A. Rice, Stacy L. Springs
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2022-06-01
Series:Molecular Therapy: Methods & Clinical Development
Assuntos:
cell therapy products
sterility test
microbial contamination
mass spectrometry
metabolomics
microbial biomarker
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2329050122000547
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