Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

<abstract language="eng">Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity. Many efforts have been done to overcome MDR based on studies of structure-activity relation...

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Bibliographic Details
Main Authors: Paula C. Huber, Cintia H. Maruiama, Wanda P. Almeida
Format: Artigo
Language:Inglês
Published: Sociedade Brasileira de Química 2010-01-01
Series:Química Nova
Subjects:
P-glycoprotein
multidrug resistance
modulators
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000027
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