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Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

<abstract language="eng">Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity. Many efforts have been done to overcome MDR based on studies of structure-activity relation...

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Hlavní autoři: Paula C. Huber, Cintia H. Maruiama, Wanda P. Almeida
Médium: Artigo
Jazyk:Inglês
Vydáno: Sociedade Brasileira de Química 2010-01-01
Edice:Química Nova
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On-line přístup:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010001000027
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