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Computation predicts rapidly adapting mechanotransduction currents cannot account for tactile encoding in Merkel cell-neurite complexes.

Distinct firing properties among touch receptors are influenced by multiple, interworking anatomical structures. Our understanding of the functions and crosstalk of Merkel cells and their associated neurites-the end organs of slowly adapting type I (SAI) afferents-remains incomplete. Piezo2 mechanic...

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Autors principals: Gregory J Gerling, Lingtian Wan, Benjamin U Hoffman, Yuxiang Wang, Ellen A Lumpkin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science (PLoS) 2018-06-01
Col·lecció:PLoS Computational Biology
Accés en línia:http://europepmc.org/articles/PMC6042796?pdf=render
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