Fascin-1 enhances experimental osteosarcoma tumor formation and metastasis and is related to poor patient outcome

Abstract Background Fascin-1, a prominent actin-bundling protein, is found to be upregulated in several human carcinomas. While it is accepted that Fascin-1 expression correlates with poor clinical outcome and decreased survival in various carcinomas, its role in sarcoma such as osteosarcoma (OS) re...

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Bibliografiska uppgifter
Huvudupphovsmän: Matthias J. Arlt, Aleksandar Kuzmanov, Jess G. Snedeker, Bruno Fuchs, Unai Silvan, Adam A. Sabile
Materialtyp: Artigo
Språk:Inglês
Publicerad: BMC 2019-01-01
Serie:BMC Cancer
Ämnen:
Fascin-1
Osteosarcoma
Metastasis
Xenograft mouse model
MMP9
Länkar:http://link.springer.com/article/10.1186/s12885-019-5303-3
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