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Pre-clinical blocking of PD-L1 molecule, which expression is down regulated by NF-κB, JAK1/JAK2 and BTK inhibitors, induces regression of activated B-cell lymphoma

Abstract Escape from immune control must be important in the natural course of B-cell lymphomas, especially for those with activation of NF-κB. The pre-clinical LMP1/CD40-expressing transgenic mouse model is characterized by B-cell specific CD40 signaling responsible for NF-κB continuous activation...

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主要な著者: Christelle Vincent-Fabert, Lilian Roland, Ursula Zimber-Strobl, Jean Feuillard, Nathalie Faumont
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2019-08-01
シリーズ:Cell Communication and Signaling
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オンライン・アクセス:http://link.springer.com/article/10.1186/s12964-019-0391-x
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