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Structural and biochemical evidence that ATP inhibits the cancer biomarker human aldehyde dehydrogenase 1A3

Three X-ray structures are presented of human aldehyde dehydrogenase family 1 member A3 (ALDH1A3), a potential cancer stem cell biomarker (alone, with NAD+ and with ATP) and structure determination performed using molecular replacement.

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Detalhes bibliográficos
Main Authors: Albert Castellví, Raquel Pequerul, Vito Barracco, Judith Juanhuix, Xavier Parés, Jaume Farrés
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2022-04-01
Colecção:Communications Biology
Acesso em linha:https://doi.org/10.1038/s42003-022-03311-1
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