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Effects of MUL1 and PARKIN on the circadian clock, brain and behaviour in Drosophila Parkinson’s disease models

Abstract Background Mutants which carry mutations in genes encoding mitochondrial ligases MUL1 and PARKIN are convenient Drosophila models of Parkinson’s disease (PD). In several studies it has been shown that in Parkinson’s disease sleep disturbance occurs, which may be the result of a disturbed ci...

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Main Authors: Bartosz Doktór, Milena Damulewicz, Elżbieta Pyza
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2019-05-01
Colecção:BMC Neuroscience
Assuntos:
ROS
Acesso em linha:http://link.springer.com/article/10.1186/s12868-019-0506-8
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