The epigenetic modifiers 5-aza-2'-deoxycytidine and trichostatin A influence adipocyte differentiation in human mesenchymal stem cells

Epigenetic mechanisms such as DNA methylation and histone modification are important in stem cell differentiation. Methylation is principally associated with transcriptional repression, and histone acetylation is correlated with an active chromatin state. We determined the effects of these epigeneti...

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Autori principali: J. Zych, M.A. Stimamiglio, A.C. Senegaglia, P.R.S. Brofman, B. Dallagiovanna, S. Goldenberg, A. Correa
Natura: Artigo
Lingua:Inglês
Pubblicazione: Associação Brasileira de Divulgação Científica 2013-05-01
Serie:Brazilian Journal of Medical and Biological Research
Soggetti:
Mesenchymal stem cells
Trichostatin A
5-Aza-2′-deoxycytidine
Adipocyte differentiation
Epigenetics
Accesso online:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000500405
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