Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer Cells

Combinations of gemcitabine and trabectedin exert modest synergistic cytotoxic effects on two pancreatic cancer cell lines. Here, systems pharmacodynamic (PD) models that integrate cellular response data and extend a prototype model framework were developed to characterize dynamic changes in cell cy...

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Main Authors: Xin Miao, Gilbert Koch, Sihem Ait-Oudhia, Robert Straubinger, William J. Jusko
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2016-11-01
Serier:Frontiers in Pharmacology
Fag:
Cell Cycle
Pancreatic Cancer
gemcitabine
drug combination
Trabectedin
Pharmacodynamic models
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00421/full
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