Direct bone marrow injection of human bone marrow-derived stromal cells into mouse femurs results in greater prostate cancer PC-3 cell proliferation, but not specifically proliferation within the injected femurs

Abstract Background While prostate cancer (PCa) cells most often metastasize to bone in men, species-specific differences between human and mouse bone marrow mean that this pattern is not faithfully replicated in mice. Herein we evaluated the impact of partially humanizing mouse bone marrow with hum...

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Hlavní autoři: Bianca Nowlan, Elizabeth D. Williams, Michael Robert Doran
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2022-05-01
Edice:BMC Cancer
Témata:
Prostate cancer
Bone marrow
Bone marrow mesenchymal stem cell
Bone marrow stromal cell
Mouse models
Humanization
On-line přístup:https://doi.org/10.1186/s12885-022-09430-6
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