Improving Production of Tacrolimus In Streptomyces Tacrolimicus (ATCC 55098) Through Development of Novel Mutant by Dual Mutagenesis

ABSTRACT Tacrolimus is a polyketide macrolide produced by Streptomyces species which is widely used as anti-fibrotic agent and potent immunosuppressant. In this article dual mutagenesis approach using mutagens (NTG+EMS+UV) was used to develop a mutant strain of Streptomyces tacrolimicus (ATCC 55098)...

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Main Authors: Bhanu P Singh, Punit Kumar, Shafiul Haque, Arshad Jawed, Kashyap Kumar Dubey
Formato: Artigo
Idioma:Inglês
Publicado: Instituto de Tecnologia do Paraná (Tecpar) 2017-08-01
Series:Brazilian Archives of Biology and Technology
Assuntos:
Immunosuppressant
Macrolide polyketide
Tacrolimus
Mutagenesis
Acceso en liña:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100419&lng=en&tlng=en
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