A human beta cell line with drug inducible excision of immortalizing transgenes

Objectives: Access to immortalized human pancreatic beta cell lines that are phenotypically close to genuine adult beta cells, represent a major tool to better understand human beta cell physiology and develop new therapeutics for Diabetes. Here we derived a new conditionally immortalized human beta...

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Main Authors: Marion Benazra, Marie-José Lecomte, Claire Colace, Andreas Müller, Cécile Machado, Severine Pechberty, Emilie Bricout-Neveu, Maud Grenier-Godard, Michele Solimena, Raphaël Scharfmann, Paul Czernichow, Philippe Ravassard
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2015-12-01
Serier:Molecular Metabolism
Fag:
Cell engineering
Human pancreatic beta cell line
Conditional immortalization
Tamoxifen inducible CRE
Human beta cell function
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877815001787
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