C/EBP-Induced Transdifferentiation Reveals Granulocyte-Macrophage Precursor-like Plasticity of B Cells

The lymphoid-myeloid transdifferentiation potentials of members of the C/EBP family (C/EBPα, β, δ, and ε) were compared in v-Abl-immortalized primary B cells. Conversion of B cells to macrophages was readily induced by the ectopic expression of any C/EBP, and enhanced by endogenous C/EBPα and β acti...

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Detalhes bibliográficos
Main Authors: Branko Cirovic, Jörg Schönheit, Elisabeth Kowenz-Leutz, Jelena Ivanovska, Christine Klement, Nina Pronina, Valérie Bégay, Achim Leutz
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-02-01
Colecção:Stem Cell Reports
Assuntos:
hematopoiesis
leukemia
differentiation
stem cell
progenitor
lineage switch
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213671116303058
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