Human adenovirus type 5 vectors deleted of early region 1 (E1) undergo limited expression of early replicative E2 proteins and DNA replication in non-permissive cells.

Adenovirus (Ad) vectors deleted of the early region 1 (E1) are widely used for transgene delivery in preclinical and clinical gene therapy studies. Although proteins encoded within the E1 region are required for efficient virus replication, previous studies have suggested that certain viral or cellu...

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Main Authors: Bratati Saha, Robin J Parks
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science (PLoS) 2017-01-01
Serija:PLoS ONE
Online dostop:http://europepmc.org/articles/PMC5507307?pdf=render
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