Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

Abstract Background Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics...

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Auteurs principaux: Aditya Vijay Bhagwate, Yuanhang Liu, Stacey J. Winham, Samantha J. McDonough, Melody L. Stallings-Mann, Ethan P. Heinzen, Jaime I. Davila, Robert A. Vierkant, Tanya L. Hoskin, Marlene Frost, Jodi M. Carter, Derek C. Radisky, Julie M. Cunningham, Amy C. Degnim, Chen Wang
Format: Artigo
Langue:Inglês
Publié: BMC 2019-09-01
Collection:BMC Genomics
Sujets:
DNA sequencing
Target sequencing panel
Formalin-fixed tissue
Breast tissue
Mutational signature
Molecular barcode
Accès en ligne:http://link.springer.com/article/10.1186/s12864-019-6056-8
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