Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples

Abstract Background Archived formalin fixed paraffin embedded (FFPE) samples are valuable clinical resources to examine clinically relevant morphology features and also to study genetic changes. However, DNA quality and quantity of FFPE samples are often sub-optimal, and resulting NGS-based genetics...

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Main Authors: Aditya Vijay Bhagwate, Yuanhang Liu, Stacey J. Winham, Samantha J. McDonough, Melody L. Stallings-Mann, Ethan P. Heinzen, Jaime I. Davila, Robert A. Vierkant, Tanya L. Hoskin, Marlene Frost, Jodi M. Carter, Derek C. Radisky, Julie M. Cunningham, Amy C. Degnim, Chen Wang
格式: Artigo
語言:Inglês
出版: BMC 2019-09-01
叢編:BMC Genomics
主題:
DNA sequencing
Target sequencing panel
Formalin-fixed tissue
Breast tissue
Mutational signature
Molecular barcode
在線閱讀:http://link.springer.com/article/10.1186/s12864-019-6056-8
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