Transgenic Rescue of Spermatogenesis in Males With Mgat1 Deleted in Germ Cells

MGAT1 and complex N-glycans are required for spermatogenesis and fertility. Conditional deletion of Mgat1 in spermatogonia (Mgat1 cKO) causes reduced ERK1/2 signaling and the formation of multinucleated germ cells (MNC). Here we show that glycomics analysis of N-glycans released from fixed testis se...

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Main Authors: Barnali Biswas, Frank Batista, Ayodele Akintayo, Jennifer Aguilan, Pamela Stanley
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-04-01
Colecção:Frontiers in Cell and Developmental Biology
Assuntos:
spermatogenesis
MGAT1
N-glycans
fertility
transgenic rescue
Acesso em linha:https://www.frontiersin.org/article/10.3389/fcell.2020.00212/full
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