Trastuzumab: updated mechanisms of action and resistance in breast cancer

HER2-postitive breast cancer has the second-poorest prognosis among breast cancer subtypes. One of the most effective targeted therapies for patients with HER2-positive breast cancer is trastuzumab-based. However, primary or acquired resistance to trastuzumab has been a major obstacle in the clinica...

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Main Authors: Francois X. Claret, Thuy T Vu
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2012-06-01
Serier:Frontiers in Oncology
Fag:
breast cancer
targeted therapies
HER2/ERBB2
HER3
Herceptin
trastuzumab
Online adgang:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00062/full
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