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Mutagenesis-mediated decrease of pathogenicity as a feature of the mutant spectrum of a viral population.

BACKGROUND: RNA virus populations are heterogeneous ensembles of closely related genomes termed quasispecies. This highly complex distribution of variants confers important properties to RNA viruses and influences their pathogenic behavior. It has been hypothesized that increased mutagenesis of vira...

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Detalhes bibliográficos
Main Authors: Marta Sanz-Ramos, Teresa Rodríguez-Calvo, Noemí Sevilla
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3386257?pdf=render
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