ASIC3 knockout alters expression and activity of P2X3 in muscle afferent nerves of rat model of peripheral artery disease

Abstract In peripheral artery disease (PAD), the metaboreceptor and mechanoreceptor in muscle afferent nerves contribute to accentuated sympathetic outflow via a neural reflex termed exercise pressor reflex (EPR). Particularly, lactic acid and adenosine triphosphate (ATP) produced in exercising musc...

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Bibliographic Details
Main Authors: Lu Qin, Qin Li, Jianhua Li
Format: Artigo
Language:Inglês
Published: Wiley 2022-05-01
Series:FASEB BioAdvances
Subjects:
ASIC
blood pressure
dorsal root ganglion
hindlimb ischemia
muscle afferent
P2X
Online Access:https://doi.org/10.1096/fba.2021-00156
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