A Novel Single-Strand RNAi Therapeutic Agent Targeting the (Pro)renin Receptor Suppresses Ocular Inflammation

The receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to the (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent intracellular signaling. Here we revealed significant upregulation of prorenin...

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Main Authors: Atsuhiro Kanda, Erdal Tan Ishizuka, Atsushi Shibata, Takahiro Matsumoto, Hidekazu Toyofuku, Kousuke Noda, Kenichi Namba, Susumu Ishida
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2017-06-01
Serija:Molecular Therapy: Nucleic Acids
Teme:
(pro)renin receptor
receptor-associated prorenin system
renin-angiotensin system
inflammation
angiogenesis
molecular targeting therapy
RNA interference
Online dostop:http://www.sciencedirect.com/science/article/pii/S2162253117300021
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