Orphan Nuclear Receptor NR4A2 Is Constitutively Expressed in Cartilage and Upregulated in Inflamed Synovium From hTNF-Alpha Transgenic Mice

Orphan nuclear receptor 4A2 (NR4A2/Nurr1) is a constitutively active transcription factor with potential roles in the onset and progression of inflammatory arthropathies. NR4A2 is overexpressed in synovium and cartilage from individuals with rheumatoid arthritis (RA), psoriatic arthritis, and osteoa...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Cullen M. Lilley, Andrea Alarcon, My-Huyen Ngo, Jackeline S. Araujo, Luis Marrero, Kimberlee S. Mix
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2022-04-01
Saila:Frontiers in Pharmacology
Gaiak:
nuclear receptors
NR4A2 gene
NFkB (RelA)
TNF-α
cartilage
synovium
Sarrera elektronikoa:https://www.frontiersin.org/articles/10.3389/fphar.2022.835697/full
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