Launching a novel preclinical infrastructure: comparative oncology trials consortium directed therapeutic targeting of TNFalpha to cancer vasculature.

Under the direction and sponsorship of the National Cancer Institute, we report on the first pre-clinical trial of the Comparative Oncology Trials Consortium (COTC). The COTC is a novel infrastructure to integrate cancers that naturally develop in pet dogs into the development path of new human drug...

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Bibliographic Details
Main Authors: Melissa C Paoloni, Anita Tandle, Christina Mazcko, Engy Hanna, Stefan Kachala, Amy Leblanc, Shelley Newman, David Vail, Carolyn Henry, Douglas Thamm, Karin Sorenmo, Amin Hajitou, Renata Pasqualini, Wadih Arap, Chand Khanna, Steven K Libutti
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2659423?pdf=render
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