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Evidence on Integrating Pharmacokinetics to Find Truly Therapeutic Agent for Alzheimer’s Disease: Comparative Pharmacokinetics and Disposition Kinetics Profiles of Stereoisomers Isorhynchophylline and Rhynchophylline in Rats

Isorhynchophylline (IRN) and rhynchophylline (RN), a pair of stereoisomers, are tetracyclic oxindole alkaloids isolated from Uncaria rhynchophylla, a commonly used Chinese medicinal herb. These two compounds have drawn extensive attention due to their potent neuroprotective effects with promising th...

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Detalhes bibliográficos
Main Authors: Chunyuan Zhang, Xu Wu, Yanfang Xian, Lin Zhu, Ge Lin, Zhi-Xiu Lin
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Limited 2019-01-01
Colecção:Evidence-Based Complementary and Alternative Medicine
Acesso em linha:http://dx.doi.org/10.1155/2019/4016323
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