Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

Abstract Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compounds had antibacterial activity. Interestingly, compounds 1, 2, 3, 10 and 15 displaye...

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Main Authors: Btissam Bouchal, Farid Abrigach, Abdelilah Takfaoui, Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Pierre H. Dixneuf, Henri Doucet, Rachid Touzani, Mohammed Bellaoui
Formato: Artigo
Idioma:Inglês
Publicado: BMC 2019-08-01
Series:BMC Chemistry
Assuntos:
Imidazole
Antifungal
Antibacterial
Structure–activity relationship
ADME–Tox
Docking
Acceso en liña:http://link.springer.com/article/10.1186/s13065-019-0623-6
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