Identification of novel antifungal agents: antimicrobial evaluation, SAR, ADME–Tox and molecular docking studies of a series of imidazole derivatives

Abstract Thirty-four imidazole-based compounds synthesized by one-pot catalytic method were evaluated for their antifungal and antibacterial activities against several fungal and bacterial strains. None of the compounds had antibacterial activity. Interestingly, compounds 1, 2, 3, 10 and 15 displaye...

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Bibliographic Details
Main Authors: Btissam Bouchal, Farid Abrigach, Abdelilah Takfaoui, Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Pierre H. Dixneuf, Henri Doucet, Rachid Touzani, Mohammed Bellaoui
Format: Artigo
Language:Inglês
Published: BMC 2019-08-01
Series:BMC Chemistry
Subjects:
Imidazole
Antifungal
Antibacterial
Structure–activity relationship
ADME–Tox
Docking
Online Access:http://link.springer.com/article/10.1186/s13065-019-0623-6
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