A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol

Abstract Background Tubal ectopic pregnancy (tEP) is the most common life-threatening condition in gynaecology. Treatment options include surgery and medical management. Stable women with tEPs with pre-treatment serum human chorionic gonadotrophin (hCG) levels < 1000 IU/L respond well to outpatie...

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Hauptverfasser: James May, Colin Duncan, Ben Mol, Siladitya Bhattacharya, Jane Daniels, Lee Middleton, Catherine Hewitt, Arri Coomarasamy, Davor Jurkovic, Tom Bourne, Cecilia Bottomley, Alexandra Peace-Gadsby, Ann Doust, Stephen Tong, Andrew W. Horne
Format: Artigo
Sprache:Inglês
Veröffentlicht: BMC 2018-11-01
Schriftenreihe:Trials
Schlagworte:
Gynaecology
Reproductive medicine
Ectopic pregnancy
Gefitinib
Epidermal growth factor receptor
Methotrexate
Online Zugang:http://link.springer.com/article/10.1186/s13063-018-3008-6
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