Discovery of Benzo[f]indole-4,9-dione Derivatives as New Types of Anti-Inflammatory Agents

Certain benzo[f]indole-4,9-dione derivatives were synthesized and evaluated for their inhibitory effects on superoxide anion generation and neutrophil elastase (NE) release in formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLF)-activated human neutrophils. Results indicated that (Z)-1-benzyl-4-(hydr...

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Auteurs principaux: You-Ren Chen, Chih-Hua Tseng, Yeh-Long Chen, Tsong-Long Hwang, Cherng-Chyi Tzeng
Format: Artigo
Langue:Inglês
Publié: MDPI AG 2015-03-01
Collection:International Journal of Molecular Sciences
Sujets:
benzo[f]indole-4,9-dione derivatives
superoxide anion generation
elastase release
anti-inflammatory agents
Accès en ligne:http://www.mdpi.com/1422-0067/16/3/6532
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